Malvern Zetasizer Nano Series

Attention: open in a new window. PDFPrintE-mail

malvernThe Zetasizer Nano range of instruments provides the ability to measure three characteristics of particles or molecules in a liquid medium.

These three fundamental parameters are Particle size, Zeta potential and Molecular weight. By using the unique technology within the Zetasizer system these parameters can be measured over a wide range of concentrations. The Zetasizer system also enables determination of the Protein melting point plus the ability to perform Trend and Autotitration measurements.

 The Zetasizer range features pre-aligned optics and programmable measurement position plus the precise temperature control necessary for reproducible, repeatable and accurate measurements. In addition facility is included for measurements of other key parameters such as pH and concentration.

The Zetasizer range has been designed with simplicity in mind, so that a minimal amount of user interaction is necessary to achieve excellent results. The use of Standard Operating Procedures (SOPs) and features such as the folded capillary cell alleviate the need for constant attention

The new technology incorporated in these systems provides unequalled sensitivity and versatility. The patented NIBS optics incorporated into the Nano ZS also allows measurements of samples with little or no dilution


  • Model: Nano ZS(green badge)
  • Model no: ZEN3500
  • Size range: 0.6nm to 10um
  • Size range for zeta potential: 5nm to 10um
  • Size range for molecular weight: 1000 to 2x1000 Daltons
  • Laser fitted: 532nm 50mW green laser
  • MPT-2 autotitrator: performs ph additive dilution titration


Particle Size- NIBS technology enables measurements of particles and molecules from 0.6nm to 6 microns. The Zetasizer system determines the size by first measuring the Brownian motion of the particles in a sample using Dynamic Light Scattering (DLS) and then interpreting a size from this using established theories.

Zeta Potential - The Zetasizer Nano series calculates the zeta potential by determining the Electrophoretic Mobility and then applying the Henry equation. To perform measurements at any point within a cell and obtain the electrophoretic mobility Malvern has developed its patented M3-PALStechnique. This technique enables accurate measurements of zeta potential in aqueous and non-aqueous dispersions. This is a combination of Malvern’s improved laser Doppler velocimetry method - the M3 measurement technique, and the application of PALS (Phase Analysis Light Scattering).

Molecular Weight - An avalanche-photodiode detector and fiber detection optics give the sensitivity and stability required for absolute molecular weight measurement With the Zetasizer Nano series of instruments the molecular weight can now be determined by use of Static Light Scattering (SLS) measurement techniques.

For more details visit-